We already have candidate drugs designated for 1,079 rare diseases. Patients can actually get one for 392 of them. Four decades separate those two numbers, and almost none of that gap happened in a lab. An orphan drug designation means a company already has a molecule and a target. Discovery is done. Since 1983 the FDA has granted 6,340 of them. Only 882 ever became an approved drug. So the funnel has already been stress tested at scale, and 85% of the loss happens after the chemistry…