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Moderna just became the first company in history to pass a Phase 3 trial with a personalized cancer vaccine. Every single dose is a different drug. Here's how it works. Surgeons remove the melanoma, then sequence the tumor's DNA and RNA. An algorithm compares it against the patient's healthy cells and picks up to 34 mutations unique to that one person's cancer. Those mutations get encoded into a custom mRNA strand, wrapped in lipid nanoparticles, and injected. The immune system reads theā¦