LatchBio researcher @arjunomics reveals Grok's refusals often come from the model itself while Fable and GPT-5.6 Sol rely more on external safety layers: "There might be input classifiers where when a user puts in a query, the model initially might say, this is a bad query, we can't respond to this. There might also be output classifiers, so after the model outputs a query, you might have an external classifier that says, no, don't show this query, put it in an API block. And there are also…

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LatchBio evaluated Grok’s performance on biosecurity monitoring and adversarial biological tasks. They found that Grok 4.6 correctly detects and refuses dangerous queries, including maliciously obfuscated biological tasks, while also allowing beneficial scientific queries to be answered. We discuss these results in a blog post: https://x.ai/news/biosafety-at-the-frontier