Very interested in what the coming era of highly bespoke software might look like. Example from this morning - I've become a bit loosy goosy with my cardio recently so I decided to do a more srs, regimented experiment to try to lower my Resting Heart Rate from 50 -> 45, over experiment duration of 8 weeks. The primary way to do this is to aspire to a certain sum total minute goals in Zone 2 cardio and 1 HIIT/week. 1 hour later I vibe coded this super custom dashboard for this very specific experiment that shows me how I'm tracking. Claude had to reverse engineer the Woodway treadmill cloud API to pull raw data, process, filter, debug it and create a web UI frontend to track the experiment. It wasn't a fully smooth experience and I had to notice and ask to fix bugs e.g. it screwed up metric vs. imperial system units and it screwed up on the calendar matching up days to dates etc. But I still feel like the overall direction is clear: 1) There will never be (and shouldn't be) a specific app on the app store for this kind of thing. I shouldn't have to look for, download and use some kind of a "Cardio experiment tracker", when this thing is ~300 lines of code that an LLM agent will give you in seconds. The idea of an "app store" of a long tail of discrete set of apps you choose from feels somehow wrong and outdated when LLM agents can improvise the app on the spot and just for you. 2) Second, the industry has to reconfigure into a set of services of sensors and actuators with agent native ergonomics. My Woodway treadmill is a sensor - it turns physical state into digital knowledge. It shouldn't maintain some human-readable frontend and my LLM agent shouldn't have to reverse engineer it, it should be an API/CLI easily usable by my agent. I'm a little bit disappointed (and my timelines are correspondingly slower) with how slowly this progression is happening in the industry overall. 99% of products/services still don't have an AI-native CLI yet. 99% of products/services maintain .html/.css docs like I won't immediately look for how to copy paste the whole thing to my agent to get something done. They give you a list of instructions on a webpage to open this or that url and click here or there to do a thing. In 2026. What am I a computer? You do it. Or have my agent do it. So anyway today I am impressed that this random thing took 1 hour (it would have been ~10 hours 2 years ago). But what excites me more is thinking through how this really should have been 1 minute tops. What has to be in place so that it would be 1 minute? So that I could simply say "Hi can you help me track my cardio over the next 8 weeks", and after a very brief Q&A the app would be up. The AI would already have a lot personal context, it would gather the extra needed data, it would reference and search related skill libraries, and maintain all my little apps/automations. TLDR the "app store" of a set of discrete apps that you choose from is an increasingly outdated concept all by itself. The future are services of AI-native sensors & actuators orchestrated via LLM glue into highly custom, ephemeral apps. It's just not here yet.
Claude can now securely connect to your health data. Four new integrations are now available in beta: Apple Health (iOS), Health Connect (Android), HealthEx, and Function Health.
2025 as an entrepreneur: Earned $885K with my startups Launched 3 new startups Built a $780K SaaS Made $147K in the stock market Got 107K followers on 𝕏 Read 10 books Traveled to 9 countries Exercised for 340+ days Gained 4kg of muscles Walked 4.2M steps Top 1% sleep score on WHOOP Reached 57.4 mg/kg/min VO₂ max Reached <18 yo biological age Drank 0L of alcohol Spent 365 days with my wife I hope 2026 unfolds like 2025: peace of mind, discipline, more startups. Happy New Year
Every day, millions of people ask ChatGPT about their health – from breaking down medical information, preparing questions for their doctor's appointments, to helping people manage their overall wellbeing.
Anthropic launched Claude for Healthcare with HIPAA-ready products and expanded Claude for Life Sciences with new connectors ranging from clinical trial management to regulatory operations - Claude for Healthcare connects to Centers for Medicare and Medicaid Services Coverage Database, International Classification of Diseases 10th Revision codes, and National Provider Identifier Registry, with new Agent Skills for FHIR development and a sample prior authorization review skill that can be customized to organizations' policies - US Claude Pro and Max plan subscribers get beta access to HealthEx and Function connectors now, with Apple Health and Android Health Connect integrations rolling out in beta this week on iOS and Android apps for accessing lab results and health records - Claude for Life Sciences adds connectors to Medidata for trial data and site performance, ClinicalTrials[.]gov, ToolUniverse with 600+ vetted scientific tools, bioRxiv and medRxiv preprint servers, Open Targets, ChEMBL, and Owkin Pathology Explorer for tissue image analysis - New Agent Skills for scientific problem selection, converting instrument data to Allotrope, scVI-tools and Nextflow deployment for bioinformatics, and a sample skill for clinical trial protocol draft generation with endpoint recommendations accounting for regulatory pathways, competitive landscape, and FDA guidelines - Anthropic is hosting "The Briefing: Healthcare and Life Sciences", a free livestreamed virtual event on January 12 at 11:30 AM PST with Anthropic leadership and customer perspectives on AI in healthcare
Skate spot is swarmed by Super Bowl stuff and an anti circumcision protest lol. Will still be here an hour or two at least
This podcast with @collision is now on YouTube too 😊 youtube.com/watch?v=StkCdc
2025 as a solopreneur: - $2.834M+ in revenue - Operated at ~91% margins - Sunset my 2 top products - 134K new followers on LinkedIn - 45K new followers on 𝕏 - Traveled domestically 12x - Traveled internationally 8x - Threw 7 small masterminds - Exercised 348 days - Walked 2,460 miles & 6.15M steps - Lost 8 pounds - Took my wife to lunch 60x - Visited 10+ breweries - Lived abroad for 60 days - Flew our parents on vacation first class Life came first, business supported it.
Researchers built SleepFM, a model that analyzes one night of sleep-study signals—brain, heart, breathing, and movement—to identify over 130 conditions, including Alzheimer’s, Parkinson’s, stroke, and heart failure, up to six years before symptoms appear. The work suggests routine sleep monitoring could become an early-warning system for major illnesses. https://hubs.ly/Q045skwt0
SleepFM Detects Signs of Neurological Disorders Years Before Symptoms Manifest
OpenAI has acquired @TorchHealth The Torch team and I are joining OAI to help build ChatGPT Health into the best AI tool in the world for health and wellness.
.@celltypeinc is building the agentic drug company. AI agents + foundation models that simulate human biology. They've already discovered and validated a novel cancer treatment signal and work with Top 10 pharma. Congrats on the launch @david_van_dijk and @vrkici! https://ycombinator.com/launches/PSn-cel…
.@tryprana is an AI primary doctor in your pocket that monitors you 24/7. Connect your wearables to your medical records to monitor for clinical drift. At any moment, you can instantly bring a Board-Certified MD into the chat to review your vitals, answer questions, and manage your care. Passive monitoring. Active care. http://pranadoc.com Congrats on the launch @_meerpatel, @smenon21, @vishrawal_! https://ycombinator.com/launches/PPg-pra…
