My 2026 AI predictions podcast with @reidhoffman—LinkedIn cofounder, Microsoft board member, and former OpenAI board member: Reid’s spiciest predictions: - If you’re not recording every single meeting and using agents to amplify your work process, it’s going to feel like using a horse and buggy vs. a car. - AI becomes the scapegoat for everything—electricity prices, eggs, jobs. Most blame will be wrong, but some real impacts will also start hitting. This will make the discourse uglier. - No major AI player will have a major stumble. It will continue being a close horse race. But OpenAI will learn how to play catch up instead of always playing with a lead. - 10x to 100x more people will have their computer doing work for them while they’re out doing other things—agents break out beyond coding. - Apple continues to be behind in AI and the gap will be “stunning.” Dan’s spiciest predictions: - Programming trifurcates into three skills: traditional engineering + AI, vibe coding, and a new third thing—agentic engineering (think highly technical engineer with 4 Claude Code tabs open at once, never looking at code). - OpenAI realizes it is missing the most valuable coding market because they’re stuck in the innovators dilemma: caught between serving traditional engineers + AI, or agentic engineers. - Creation becomes the new addiction as the dopamine hit of making things with Claude Code and other tools starts to spread. AI commandments that are most likely to be broken this year: - Interpretability: We’ll allow models to communicate with each other in non-human readable formats, and it will work.—Reid - Alignment: We’ll realize that more disagreeable AI that forms its own opinions are quite useful as autonomy increases. This will be more likely as orchestrators get better—the orchestrator can deal with the pain-in-the-ass model, instead of the user.—Dan Reid’s pick for most underrated AI category in 2026: Biology. There’s a chance we find a “move 37” in bio this year. Watch below! Timestamps: Introduction: 00:00:52 The future of work is an entrepreneurial mindset: 00:02:20 Creation is addictive (and that’s okay): 00:05:22 Why discourse around AI might get uglier this year: 00:09:22 AI agents will break out of coding in 2026: 00:17:03 What makes Anthropic’s Opus 4.5 such a good model: 00:24:18 Who will win the agentic coding race: 00:28:46 Why enterprise AI will finally land this year: 00:36:13 How Reid defines AGI: 00:43:16 The most underrated category to watch in AI right now: 00:55:33